منابع مشابه
Do electrostatic interactions with positively charged active site groups tighten the transition state for enzymatic phosphoryl transfer?
The effect of electrostatic interactions on the transition-state character for enzymatic phosphoryl transfer has been a subject of much debate. In this work, we investigate the transition state for alkaline phosphatase (AP) using linear free-energy relationships (LFERs). We determined k(cat)/K(M) for a series of aryl sulfate ester monoanions to obtain the Brønsted coefficient, beta(lg), and com...
متن کاملEnzyme-catalyzed phosphoryl transfer reactions.
PERSPECTIVES AND SUMMARY ................... ... ...................................................... 877 Classes of enzyme involving reactions at phosphorus...................................................... 878 COVALENT REACTION INTERMEDIATES, CRYPTIC AND OTHERWISE........................................................................................................ 879 Reactions of Pho...
متن کاملModels for biological phosphoryl transfer.
Quantifying the rate of phosphate monoester dianion hydrolysis under physiological conditions has implications for designing transition state mimics and understanding how catalysis is facilitated. Catalysis is energetically most efficient if the mechanistic pathway in solution is stabilised. Monoesters are believed to have a "dissociative" transition state that has little bonding to the nucleop...
متن کاملPhosphagen kinases catalyze the reversible transfer of a high-energy phosphoryl group from phosphorylated guanidino
high-energy phosphoryl group from phosphorylated guanidino storage compounds known as phosphagens to ADP in the following general reaction: phosphagen + MgADP + H+ ↔ guanidino acceptor + MgATP. These reactions are typically found in cells that display high and variable rates of energy turnover, such as muscle fibers, neurons, spermatozoa and transport epithelia (Ellington, 2001). Phosphagen kin...
متن کاملHow do nonreproductive groups affect population growth?
I describe several models of population dynamics, both unstructured and gender structured, that include groups of individuals who do not reproduce. I analyze the effect that the nonreproductive group may have on the dynamics of the whole population in terms of the vital rates and the proportion of nonreproductive individuals, and we provide specific examples for real populations.
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ژورنال
عنوان ژورنال: Structure
سال: 1998
ISSN: 0969-2126
DOI: 10.1016/s0969-2126(98)00043-4